lab sculpture created by Steve Lohman


Voltage trace (A) and phase plane trajectory (B) of a rebound depolarization driven by a conditioned stimulus in a model DCN neuron, following training with an intermediate interstimulus int erval (ISI) of 90 ms. The stochastic arrival times of synaptic inputs leads to variations in the voltage dynamics between the 20 traces shown, despite identical initial conditions at t = -100 ms (red and blue traces). This ISI value leads to unreliable retrieval of the stored memory. Noisy synaptic inputs lead some phase plane trajectories (red dots) closer to the reliable retrieval zone (warm colors in color map) and toward a higher level of deinactivation of T-type Ca2+ channels, while other trajectories are more distant from the reliable retrieval zone (blue dots).



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