Mark Schnitzer Principal Investigator

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CURRICULUM VITAE

Mark Schnitzer is Professor of Biology and Applied Physics and is an Investigator of the Howard Hughes Medical Institute. His research concerns the innovation of novel optical imaging technologies and their use in the pursuit of understanding neural circuits. The Schnitzer lab has invented two forms of fiber-optic imaging, one- and two-photon fluorescence microendoscopy, which enable minimally invasive imaging of cells in deep brain tissues. The lab is further developing microendoscopy technology, studying how experience or environment alters neuronal properties, and exploring two different clinical applications. The group has also developed two complementary approaches to imaging neuronal and astrocytic dynamics in awake behaving animals. Much research focuses on cerebellum-dependent forms of motor learning. By combining imaging, electrophysiological, behavioral, and computational approaches, the lab seeks to understand cerebellar dynamics underlying learning, memory, and forgetting. Further work in the lab concerns neural circuitry in other mammalian brain areas such as hippocampus and neocortex, as well as the neural circuitry of Drosophila.

After completing postdoctoral research in neuroscience at Stanford and Genentech, Inc., I worked as a scientist and scientific manager at Entelos, Inc., working closely with both biologists and engineers to build computer based models of disease, including asthma and other inflammatory diseases. I have returned to Stanford to apply principles of scientific management to the work in the Schnitzer lab, where innovation of new brain imaging modalities involves detailed planning and coordination between several personnel with distinct areas of expertise. I also help coordinate our relationships with scientific corporations seeking to translate our inventions into the marketplace.

Brain circuits comprise vast numbers of intricately interconnected neurons with various molecular, anatomical and physiological identities. To understand the roles of these building blocks, it is critical to develop spatio-temporally precise tools to enable neuronal subtype specific analyses with single cell precision. My focus is to develop and use light-inducible genomic modification techniques – termed optogenomics – for detailed analyses of individual neurons during mouse behavior. My overall aim is to link the functional identities of behaviorally relevant neurons with their morphological, connectional and molecular profiles.

Large-scale optical imaging of neural ensemble dynamics is nowadays the most promising way to unveil unexplored features of brain activity. During my Ph.D. studies in quantum optics, I developed new techniques of storing and imaging the spatial structure of single photons. My current research will focus on providing new optical tools to efficiently extract signals from genetically encoded neural activity indicators under hitherto technically unattainable conditions.

The perception of objects may be encoded by the coordinated neural activity of only thousands of cells. Thanks to recent technological developments, we can generally access and manipulate such information optically. My research focuses on the development of innovative optical systems that may elucidate precise causal links between neural activity and the neural representation of objects.

As a graduate student with Dr. Yi Zhong at Tsinghua University, I studied the molecular and cellular basis of olfactory long-term memory in Drosophila. In the Schnitzer lab, I am using a variety of approaches to dissect the neural circuitry underlying adaptive behavior of Drosophila. I am also involved in the effort to create massively parallel, high-throughput brain imaging technologies.

I am motivated by the possibility of uncovering hitherto unknown computational structures and concepts by careful experimental work in neuroscience. During my Ph.D. in Electrical Engineering, I developed novel optical technologies and applied them to the study of distributed brain circuits in behaving animal subjects. My current research combines multiple optical techniques, detailed studies of animal behavior, and quantitative modeling of circuits, with the aim of rigorously characterizing computational processes in the live brain.

I support the laboratory through a variety of research activities involving histology, circuit tracing, genotyping, husbandry, and surgery.

Memories are often constructed from associations between diverse pieces of information that have no intrinsic connection. By studying how disparate pieces of information are stored in relation to each other, I hope to shed light on the mechanisms by which memories are linked in the mammalian brain. This will facilitate our understanding of how higher order knowledge is extracted from multiple memories.

Sensory processing and the brain's creation of perceptions form the bedrock of our experience, and yet their neural mechanisms remain enigmatic. By studying the dynamics of cortical processing during perceptual tasks, I hope to uncover the computational principles by which representations are formed in the cortex, and the biological mechanisms that carry out such computations.

I performed my Ph.D. research at the Kavli Institute in Norway with Edvard and May-Britt Moser. My present research examines how ideas and insights arise in the brain by using large-scale optical recordings to track the dynamics of large populations of neurons in behaving animals.

Work on rodent sugeries and viral vectors.

I am Chief Resident in the Stanford Neurology Residency Program and will start a clinical fellowship in Movement Disorders at Stanford. I am interested in the neural circuits of motor learning and motor performance in animal models. I hope to use insights gained from these models to guie treatments in humans with motor control pathology, such as patients with Parkinson's disease. Before coming to Stanford, I earned my B.S. in biomedical engineering at U.Texas at Austin and my M.D. from at University of Texas Southwestern, where I studied the neural circuits of learning and memory in zebra finch songbirds.

My goal is to understand the function and coordination of specialized neural cell-types in complex circuits to enable the development of precise, targeted therapeutics. As a joint postdoc with Mark Schnitzer (Stanford) and Greg Scherrer (UNC), I am using single-cell RNA-seq to determine the molecular identity of amygdalar neurons that encode the unpleasantness associated with pain. This builds on my Ph.D. research, for which I used transcriptomics to identify unique molecular features of an exceptionally rare and specialized family of retinal neurons.

How the brain's many different types of neurons synchronize their electrical dynamics to generate extended brain oscillations is a longstanding and important question. With my joint background in neuroscience and physics, I am developing and applying new ways to probe the brain's voltage rhythms by using genetically encoded fluorescent voltage indicators.

During my Ph.D. research at Baylor College of Medicine, I developed several reversible, ratiometric fluorescent probes for glutathione. Now I am interested in applying novel techniques, especially imaging and omics-based assays, to study the molecular mechanisms underlying learning and memory and diseases thereof.

Networks of neurons are complex dynamical systems with interactions across a broad range of spatial and temporal scales. As a Ph.D. student with Haim Sompolinsky at the Hebrew University of Jerusalem, I developed theoretical and computational techniques to advance our understanding of the relationship between connectivity structure and dynamical state in such networks. Now as an Urbanek Fellow postdoctoral scholar with the Schnitzer lab and theoretical neuroscientist Prof. Surya Ganguli, I am currently applying theoretical techniques to design and analyze experiments that exploit large-scale neural recordings, with the aim of elucidating the dynamical properties underlying neural computation.

I am using genetic and optical tools developed by the Schnitzer lab to dissect and characterize the dynamics of the olfactory learning and memory circuit in adult Drosophila.

Pain is a multifaceted experience that has a powerful influence on human and animal behavior. Understanding how diverse circuits interact is critical for identifying novel, non-addictive treatments for chronic pain. Working with our lab's collaborators, I use innovative viral tools and optical techniques developed in the Schnitzer lab to dissect pathway-specific contributions to pain and pain-evoked behavioral responses.

My postdoctoral research in the Schnitzer lab focuses on optical voltage imaging studies in behaving animals.

I earned my Ph.D in neuroscience at the Univ. of Wisconsion, performing neurophysiological studies in non-human primates of the effects of anesthesia in the neocortex, thalamus, basal ganglia and other brain areas. Here in the Schnitzer lab, I am using the group's cutting-edge optical imaging techniques and mouse visual behavioral assays to study the biological basis for sensory perception at the levels of large neural ensembles and interactions between brain areas.

My studies in the Schnitzer lab focus on the neural control of movement and make use of our lab's cutting-edge optical instruments for imaging multiple brain areas concurrently in awake behaving animals. This approach builds on my experiences with electrophysiological and optical recordings in behaving rodents during my Ph.D. research (the University of Tokyo) and postdoctoral studies (Keio University, Tokyo).

It has always been intriguing to me how the brain learns new information, skills, and knowledge in a complex world. By using large-scale optical imaging techniques to study the dynamics of neural ensembles involved in learning and memory, I hope to understand experience-dependent changes in the brain circuits and to uncover computational principles governing learning in neural networks.

My interest lies at the intersection between neuroscience and computer science. Using machine learning methods and brain imaging data from mice, I aim to tap into the internal neural circuitry of the brain and understand the neural ensemble dynamics underlying memory formation and recollection in the short- and long-term. I received my undergraduate training as an electrical engineering in Turkey and my masters in theoretical physics in Canada. As an applied physics Ph.D. student at Stanford, I use a wide range of methods to tackle the interdisciplinary research questions we ask in the Schnitzer lab.

I am interested in understanding the emergent properties of large neural ensembles and the principles behind neural coding using imaging datasets and connectionist models.

I am a bioengineering Ph.D. student and am interested in uncovering the relationships between neural ensemble activity patterns in behaving animals and the macromolecular changes that support learning and memory.

My research interests are in advancing optical technologies for high-fidelity optical imaging and studying large-scale synchronous electrical activity in the mammalian brain. I am an applied physics Ph.D. student and use my training in laser physics and nonlinear optics at Moscow State University to work on interdisciplinary neuroscience research in the Schnitzer lab.

I am using the unique optical imaging technologies developed in the Schnitzer lab to better understand the means by which the brain stores and recalls episodic and associative memories. In addition to memory, I am also interested in the neural basis for cognition and executive functions.

I am interested in developing technologies that will lead to a better understanding of neural circuits in Drosophila. Specifically, I am creating machine-vision capable robots for manipulating fruit flies and compact microscopes for parallel, high-throughput brain imaging.