lab sculpture created by Steve Lohman


Voltage trace (A) and phase plane trajectory (B) of a rebound depolarization driven by a conditioned stimulus (CS) in a model deep cerebellar nuclei (DCN) neuron , following classical eyeblink conditioning with a long interstimulus interval (ISI) of 190 ms. At the start of the CS, increased spiking by Purkinje cells hyperpolarizes the DCN cell and deinactivates T-type channels. About 35 ms prior to the time of the expected US, release of the hyperpolarizing drive leads to a rebound depolarization.



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